Translationsallianz

Translationsallianz





Was ist Translation?

Translationale Forschung bildet die Schnittstelle zwischen Grundlagenforschung und der klinischen Entwicklung. Neueste Ergebnisse der Grundlagenforschung sollen so auf kurzen Wegen zu neuen Therapien oder Diagnoseverfahren für Patienten führen. Und gleichzeitig werden Fragen, die bei der klinischen Arbeit entstehen von Grundlagenforschern bearbeitet.

 

 

 

Unser Angebot

Die Partner von TRAIN verfügen über die komplette Ausrüstung und Expertise, um an jedem Entwicklungsschritt der pharmazeutischen Wertschöpfungskette den entscheidenden Mehrwert für Ihre Projekte in den Bereichen

  • ATMPS
  • Biologicals
  • Small Molecules und
  • Vakzine

zu liefern.

Wir unterstützen Sie mit einer initialen Einschätzung, um zu prüfen, ob das kommerzielle Potenzial Ihres Lead Kandidaten für eine professionelle Entwicklung  spricht.
Im Anschluss führen unsere erfahrenen Projekt Manager Ihr Projekt durch alle präklinischen Phasen zu einem klinischen Proof-of-Concept in unserer Phase I/II Prüfeinheit.
Die Bandbreite möglicher Interaktionen mit uns reicht von akademischen Forschungskooperationen bis zu Fee-for-service Vereinbarungen.



Research & Discovery

Pre-Clinical

Clinical Phase I to II

HZI

Assay
Development

Chem. Libraries
and HTS

Structural
Biology

Validation in Mice

Helmholtz Center for Infection Research (HZI)
The HZI activities are focussed in the area of Infection & Immunity. The main goal is to elucidate the processes
of microbial pathogenesis and host response to infection, in order to develop new tools and strategies to
prevent and treat infectious diseases. There are collaboration opportunities in the areas of natural products,
pharmaceutical research, vaccinology, immunology and structural biology.

LU Han

Libraries

Hit to Lead
Chemistry

Synthesis &
Optimization

Leibniz University Hannover (LUH)
The institute of Organic Chemistry at LUH has a focus on synthetic chemistry, research in oncology and infectious diseases, as well as the isolation and identification of novel APIs (e.g. plant-derived) via innovative screening and development technologies.

MHH

R&D in ATMPs, Biologics & Small Molecules
in a broad portfolio of indications

GMP (ATMP)

Phase I

Phase II

Phase III

Medical School Hannover (MHH)
Areas of specialization of the MHH include the entire range of superior services provided by a major medical facility.
In addition the MHH is internationally most renowned for transplant medicine and related immunological fields. Other focus areas are:

- Disorders of the immune system and infectious diseases (particularly of the liver)
- Oncology, pediatric and adult (male and female)
- Cardiac, vascular and respiratory medicine
- Restorative surgery, e.g. accident and emergency surgery, urology, and high-tech hearing aids (cochlear implants)

ATMPs – Deveplopment of a broad variety of Cell Therapy and Gene Therapy approaches.
Small Molecules – Argyrin

Fh ITEM

Toxicology
Pharmacology

GMP (biologics,vaccines)

Phase I

Phase II

Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM)
Services offered range from studies in the areas of occupational and environmental toxicology and consumer protection up to pre-clinical and clinical drug research and development, from allergy and asthma research up to the assessment and registration of chemicals, biocides and pesticides.

TiHo

Zoonosis –
Diagnostics & Therapeutics

Immunoprophylactic &
Vaccine Research

Animal Models

Toxicology

University of Veterinary Medicine Hannover (TiHo)
Services including clinical treatment of patients and pathological and diagnostic examinations of materials submitted; veterinary care of agricultural stock and consultation on all questions of animal husbandry, particularly the diagnosis of infections; and chemical, biochemical, or toxicological analyses.

TU BS

System
Biology

Bioinformatics

Microbiology

Technical University Carolo-Wilhelmina at Braunschweig (TU BS)
The Technical University at Braunschweig offers technical and mathematical knowhow in engineering as well as classical and molecular biology. Scientists at the Biocenter of TU BS are specialized in research in microbiology, genetics and cell biology.

Twin

Translational Research & Regulatory Expertise

TWINCORE – Center for Experimental and Clinical Infection Research
At TWINCORE medical personnel and basic research scientists from various disciplines conduct translational infection research side by side. Scientists at TWINCORE support the development of new strategies to combat infectious diseases by creating a scientific basis for risk assessment in advance of the clinical trials.

VPM

Project
Assessment

Project Management, Regulatory Interaction, Legal Sponsor of Clinical Trials

Vakzine Projekt Management GmbH (VPM)
acquires promising vaccine candidates and biopharmaceuticals from academia, develops them with a consortium of partners and commercializes the results

Establishment of German vaccines map and selection of five development projects

Successful development of VPM1002, a gene-modified live tuberculosis vaccine, from bench to bedside in four years


GPM Manufacturing Practice
ATMP Advanced Therapy Medicinal Product

22.05.2013