What is translation?


Translational research represents the interface between basic research and clinical development. The goal is to enable the latest findings from basic research to lead to new therapies or diagnostic procedures for patients in the shortest of times. At the same time, questions that arise during the clinical practice are fed back to basic research for systematic analysis.





TRAIN is an interdisciplinary association in which the infrastructure and know-how of mathematics, biology, chemistry, pharmacology, medicine, veterinary medicine and information technology are closely interlinked with one another.

This variety covers the entire field of biomedical development from basic research to application and is generating completely new options in biomedicine. What is unique about this approach is the fact that ideas are exchanged in two directions: basic researchers learn from health professionals and are thus able to align their work towards clinically relevant problems. In turn, the health professionals learn about new practical opportunities that biomedical research can offer.


The Fraunhofer Institute for Toxicology and Aerosol Research offers contract research for human and environmental health. These services include prevention of disease, toxicological research, the development of novel diagnostic methods and therapeutic concepts as well as pre-clinical and clinical trials. Research in respiratory diseases represents a focus of the institute, ranging from in-vitro testing to clinical studies in indication such as allergy, asthma and COPD.



Gottfried Wilhelm Leibnitz Universität Hannover (LUH) provides TRAIN with the extensive expertise in chemical-biological oriented active agent research of its science faculty. In addition to synthesis chemistry, infection and anti-tumour research, this also includes the isolation and identification of new active agents, particularly those derived from plants. Moreover, the biotechnology and engineering institutes also supply the knowledge for the technical implementation of the findings from basic research.



At the Helmholtz Centre for Infection Research (HZI) in Braunschweig researchers investigate the mechanisms of infections and their prevention. Understanding what makes bacteria or viruses become pathogens is the key to developing new medicines and vaccines. The focus of the researchers at the HZI lies upon vaccine research, immunology, natural substance research and structural biology.



The Hannover Medical School (MHH) is a world-renowned institute in the fields of organ and stem cell transplantation and boasts a comprehensive tissue bank. The extensive transplantation programme at the MHH – and the associated complications for the immune systems of patients – illustrates that clinical research into infectious diseases is a significant focus. From a scientific viewpoint the school is the most successful German medical teaching establishment (DFG ranking 2009) and clinically the best-performing university hospital in the field of maximum medical care.



The Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures is one of the largest biological resource centers worldwide. The unique diversity of resources, its extensive scientific services and the professional quality management makes the DSMZ an international supplier for science, diagnostic laboratories, national reference centers, as well as industrial partners of high renown. Research at the DSMZ focuses on microbial diversity, molecular mechanisms of biological interactions and tumor genesis.



The University of Veterinary Medicine Hannover (TiHo) stands for many years of expertise in veterinary medicine. It is a renowned scientific institution that combines modern science with academic tradition. Research at the TiHo is research on and for animals – and ultimately also for humans. This is particularly apparent in zoonosis research, in which infectious diseases from humans and animals interface with each other.



Technische Universität Carolo-Wilhelmina zu Braunschweig (TU BS) is the oldest technical university in Germany. The institution combines the technical and mathematical knowledge of engineering with classical and molecular biology. Researchers at the Biocenter of TU Braunschweig specialise in microbial, genetic and cell-biological research and benefit from the research portfolio of a complete university: they benefit from the knowledge of the engineers for new bioinformatic research approaches, which are going to be developed in TRAIN.



Vakine Projekt Management GmbH (VPM) acquires promising biopharmaceutical drug candidates from academia, develops them within a consortium of partners and commercializes the results. In addition VPM offers its clients individual advisory services for the development of their drug candidates, where customers benefit from VPM’s experience in translational project management. In this manner development projects can advanced into clinical stages faster, more cost-efficient and with a higher rate of success.



TWINCORE, Centre for Experimental and Clinical Research  is a joint venture between the Medizinische Hochschule Hannover and the Helmholtz-Zentrum für Infektionsforschung. At TWINCORE medical personnel and basic research scientists from various disciplines conduct infection research side by side. The focus is upon translational research - the interface between basic research and clinical development.




At the Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE) in Hannover, transdisciplinary research and development with a focus on implant research is bundled. The diverse skills in biomedical engineering of research groups from Hannover Medical School (MHH), the University of Veterinary Medicine Hannover (TiHo) and the Leibniz Universität Hannover (LUH) in cooperation with the Laser Zentrum Hannover (LZH) are efficiently combined to develope innovative and needs-based implants.